• The molecular mechanisms underlying VSMC

  2022-02-23

  

  The molecular mechanisms underlying VSMC ETB receptor upregulation have been studied after 24–48h organ culture in both coronary and cerebral arteries. The increased expression of contractile ETB receptor at these time points has been shown to depend on transcriptional mechanisms and PKC and the ext

• br Discussion Our study found that of

  2022-02-23

  

  Discussion Our study found that 62.6% of MSM from Natal had been tested for HIV before. This rate was higher than the national average of 37% estimated for the general nuciferine in 2011 and the 51.6% found by Brito et al. in MSM from 10 Brazilian cities in 2009. These rates are rather disappoin

• Imipenem australia Immunohistochemical evaluation of gastric

  2022-02-22

  

  Immunohistochemical evaluation of gastric cancer tumor samples revealed that 57.8% (59/101) were positive for GLI1, and 71.3% (72/101) stained positive for SHH [27]. Overexpression of SHH and GLI1 protein were significantly associated with larger tumor size, tumor aggressiveness, and less differenti

• Introduction Cancer has been a significant

  2022-02-22

  

  Introduction Cancer has been a significant public health problem in the world with more patients being diagnosed every year. However, chemotherapy from non-specific cytotoxic agents that as an effective means of cancer treatment is limited by severe side effects and poor selectivity. Thus, the deve

• br Discussion The present study explored that the effect

  2022-02-22

  

  Discussion The present study explored that the effect of the MTP gene −493G/T polymorphism on the risk of hepatic steatosis in Turkish patients with chronic HCV genotype 1 infection. Some researchers revealed that the MTP gene −493G/T polymorphism was associated with hepatic steatosis in CHC infe

• Two kind systems are currently available to assess the nutri

  2022-02-22

  

  Two kind systems are currently available to assess the nutritional status of cancer patients, one is largely based on some subjective parameters, the other is totally based on the objective parameters. For score systems largely based on some subjective parameters, like Nutritional Risk Screening Sco

• Recently it was found that hypoxia results in

  2022-02-22

  

  Recently, it was found that hypoxia results in the phosphorylation of β-catenin at Y654 in a Src-dependent manner (Xi et al., 2013). All β-catenin phosphorylated at this residue was found complexed with Hif1α and it was demonstrated that this β-catenin phosphorylation was required for Src to promote

• This variant has also been related to a better treatment

  2022-02-22

  

  This variant has also been related to a better treatment response in patients with metastatic colorectal cancer subjected to irinotecan-based chemotherapy (Kweekel et al., 2008). Inheritance of this metabolic variability has also been stated to influence better treatment outcomes in breast cancer pa

• One of the mechanism of

  2022-02-22

  

  One of the mechanism of regulation of NO content in plant cells is it scavenging by GSH leading to formation of GSNO [59]. This reaction, depending on NO level and availability of glutatione in its reduced form, influences cellular redox potential by lowering GSH content and in consequence may impac

• Two genes PATL and RASSF whose

  2022-02-22

  

  Two genes (PATL2 and RASSF1), whose relationship to HIV infection had not previously been reported, were identified in this study. Although PATL2 and RASSF1 have been implicated in cell division and tumor suppression, respectively (Scheller et al., 2007, Rather et al., 2014, Liu et al., 2002), their

• 17-DMAG synthesis br Introduction br Mitochondrial dysfuncti

  2022-02-22

  

  Introduction Mitochondrial dysfunction and cancer Lactate and succinate as oncometabolites Intracellular actions of lactate and succinate as tumor promoters Cell-surface receptors for lactate and succinate and their role in cancer GPR109A as the receptor for butyrate and β-hydroxybu

• The expression of heat shock proteins HSPs

  2022-02-22

  

  The expression of heat-shock proteins (HSPs) can be upregulated by viral infection, nutritional deficiency, TNF-α and oxidative stress in Bindarit [44], [45] HSPs are classified in six families (including the HSP10, HSP40, HSP60, HSP70, HSP90 and HSP100 families). HSP90 [46] for example provides a n

• Ketanserin The calculations for the R substrate showed that

  2022-02-22

  

  The calculations for the R substrate showed that, like the S substrate, the coordination shell of the Zn Ketanserin is more symmetric than in the HIC-SG crystal structure. This symmetry indicates that the enzyme could use the same reaction mechanisms as for the S substrate, but with exchanged roles

• br Treatment KD is currently

  2022-02-22

  

  Treatment KD is currently the treatment of choice for GLUT1-DS. It is a high-fat, carbohydrate-restricted diet that mimics the metabolic state of fasting; so, the KD relies an exogenous rather than body fat for ketone production, thus maintaining ketosis without weight loss. As the developing br

• br Acknowledgements This work was financed by

  2022-02-22

  

  Acknowledgements This work was financed by the projects “Mejora Genética del Almendro” (MINECO-Spain, AGL2017-85042-R), “The molecular mechanisms to break flower bud dormancy in fruit trees” to RS-P within the Villum Young Investigator Program and by the VILLUM Research Center for Plant Plasticit

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