• Verapamil a calcium channel blocker used clinically as a cor

  2020-08-03

  

  Verapamil, a calcium channel blocker used clinically as a coronary vasodilator, was amongst the first compounds identified that could reverse MDR and potentiate the effects of MDR1 substrates such as vincristine [15], [16]. Verapamil, along with a number of other MDR1 blockers, have proved largely u

• The combination of brequinar and fluorouracil FU has been

  2020-08-03

  

  The combination of brequinar and 5-fluorouracil (5-FU) has been evaluated to assess whether brequinar-induced uridine depletion would improve 5-FU activity. In cells, 5-FU is metabolized into FdUMP and inhibits thymidylate synthetase, which catalyzes the formation of thymidine monophosphate from deo

• Recently a method for in vivo

  2020-07-31

  

  Recently, a method for in vivo photoactivation of gtpase inhibitor expressing PA-GFP in precise microanatomical compartments was described (Victora et al., 2010), which makes it possible to optically mark Tfh cells and track them 20 hr later (Shulman et al., 2013). Unexpectedly, it was reported tha

• br Acknowledgments The authors acknowledge funding from

  2020-07-31

  

  Acknowledgments The authors acknowledge funding from the National Key Research and Development Program of China (2016YFA0502900) and the National Science Foundation of China (31570188). Compartment Size Regulation Regulation of compartment size is one of the most fundamental issues in biology

• ICT is a product of icariin via

  2020-07-31

  

  ICT is a product of icariin via the metabolism of intestinal bacteria with an estrogen-like chemical structure where the C-3 and C-7 are hydroxylated [29], and exhibits estrogen-like activities [26], [14]. Therefore, we hypothesized that ICT had estrogen-like effects to modulate the differentiation

• At this stage it is still

  2020-07-31

  

  At this stage it is still difficult to assign specific domains to some of the regions observed in these structures, although some attempts have already been made (Brewerton et al., 2004). Clearly, higher resolution data is needed. In the future, even if an atomic structure of DNA-PKcs is determined,

• Previously a linear rolling circle amplification RCA has

  2020-07-31

  

  Previously, a linear rolling circle amplification (RCA) has been employed to create DNA nanochains or DNAzyme chains for DNA [15], miRNA [16], protein [17] detection. In RCA-based assays, target quantification is achieved through the quantification of the RCA products. In order to improve the sensit

• Our previous data showed that microsomal VgDGATs have higher

  2020-07-31

  

  Our previous data showed that microsomal VgDGATs have higher specificity for acyl substrates containing Va (Yu et al., 2006). Here, analysis of lipid Prote in transgenic soybean seeds and Stokesia and Vernonia seeds demonstrated that the Va-PC level is higher while Va-TAG is lower in the SlEPX-tran

• br Introduction Protein kinase CK is a serine

  2020-07-31

  

  Introduction Protein kinase CK2 is a serine/threonine protein kinase responsible for the phosphorylation of more than 300 physiological substrates, and plays important roles in 50 dub progression and multiple signal transduction pathways [1,2]. Increasing evidence suggests that deregulation of C

• br Conclusions In summary a

  2020-07-30

  

  Conclusions In summary, a phage screening method was developed which could be used to identify a substrate capable of conversion by the FGE. The screening was facilitated by the covalent capture of viable FGE substrates displayed on a phage library. Elution by enzymatic release using trypsin is b

• br Experimental Procedures br Author Contributions

  2020-07-30

  

  Experimental Procedures Author Contributions Acknowledgments Introduction In addition to the HLA region numerous other loci have shown association with type 1 diabetes risk [1], and susceptibility X-NeuNAc have been identified in many of these regions [2]. How these genes exert their fu

• Propidium iodide perhaps commonly used

  2020-07-30

  

  Propidium iodide, perhaps commonly used as an eDNA stain due to its role in the BacLight™ bacterial viability kits, was indeed an excellent stain for dead cells and dense eDNA structures (d), but was unable to visualize delicate eDNA structures such as those present in biofilms (). Therefore, we onl

• Roflumilast Our previous studies have demonstrated

  2020-07-30

  

  Our previous studies have demonstrated that the DDR2 discoidin domain fully contains the binding site(s) for the fibrillar collagens I and II (Leitinger, 2003, Leitinger et al., 2004). The binding site for collagen I was mapped to three spatially adjacent surface loops within the DDR2 discoidin doma

• br Limitations br Role of funding source The data

  2020-07-30

  

  Limitations Role of funding source The data for this manuscript was generated as a part of the Systematic Treatment Optimization Program for Early Mania (STOP-EM), which was supported by an unrestricted grant from AstraZeneca, Canada Study # DC-990-205. The sponsor was not involved in the desi

• In general up to date no study has considered

  2020-07-30

  

  In general, up to date, no study has considered thermodynamic modeling to estimate the Pam3CSK4 Biotin synthesis of SO2 by different DESs. Since experimental measurements are time consuming and expensive, general and accurate theoretical models are vital to estimate SO2 solubilities in different DE

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