• The aim of this study was

  2020-02-22

  

  The aim of this study was to discover and characterize a novel thermostable gluten-specific prolyl endopeptidase suitable for use during the mashing step of beer production. Subsequently to express the recombinant enzyme in E.coli and to demonstrate degradation of immunogenic gluten derived peptides

• Dysfunction of the ubiquitin proteasome system

  2020-02-22

  

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility [[7], [8], [9]]; this indicates that ubiquitination is essential for spermatogenesis and sperm function during fertilization. β-catenin i

• br Introduction The identification of genetic variants that

  2020-02-22

  

  Introduction The identification of genetic variants that influence susceptibility to Parkinson\'s disease (PD) determines functional studies, the generation of model systems and directs therapeutic strategies. To date, classical candidate gene association studies and genome-wide approaches have f

• Introduction Mycobacterium leprae the causative

  2020-02-22

  

  Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1]. Although leprosy has been eradicated from most of the countries, it still affects approximately a quarter of a million people from India [2]. Details of many bacteriol

• br O GlcNAc transferase OGT belongs to the metal

  2020-02-21

  

  O-GlcNAc transferase OGT belongs to the metal-independent GT-B superfamily of glycosyltransferases, which has been well-reviewed previously [14,15]. OGT is an essential gene encoded on the X-chromosome, and it has two main regions: a long N-terminal tetratricopeptide repeat (TPR) region and a C-t

• Upon assembly of HLA tetramers loaded with either of

  2020-02-21

  

  Upon assembly of HLA tetramers loaded with either of the two peptide versions, we could query the T cell repertoires of RA subjects and healthy individuals for the presence of cognate T BEC recognizing the respective peptide-HLA complexes. We found no significant difference in frequencies of T cell

• ApoE is secreted from astrocytes glia

  2020-02-21

  

  ApoE is secreted from astrocytes/glia into the interstitial fluid and is important for metabolizing Aβ because of its propensity for binding Aβ as a cholesterol and phospholipid acceptor in reverse cholesterol transport [8]. Aβ oligomers show a direct toxicity to neurons, and ApoE inhibits oligomer

• br Multi subunit RINGs There are RING type E s

  2020-02-21

  

  Multi-subunit RINGs There are RING-type E3s that exist as multi-subunit assemblies (see Fig. 3B). A striking example is the Cullin RING Ligase (CRL) superfamily [35], which exhibits enormous plasticity in substrate specificity. Each CRL subfamily is characterized by a cullin protein (Cul-1, 2, 3,

• Dexlansoprazole br Results br Discussion Many

  2020-02-21

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific Dexlansoprazole type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previou

• In contrast to SQLE HMGCR could be efficiently

  2020-02-21

  

  In contrast to SQLE, HMGCR could be efficiently degraded in bet inhibitor lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our rece

• Does a universal mechanism for TLS exist Our

  2020-02-21

  

  Does a universal mechanism for TLS exist? Our previous studies using the bacteriophage T4 DNA polymerase generated the model provided in Fig. 7 that quantifies the molecular forces influencing key steps in the polymerization pathway during the replication of a non-instructional versus miscoding DNA

• At the cellular level TGF has been involved in

  2020-02-21

  

  At the cellular level, TGF-β1 has been involved in the formation of invadosomes (Mandal et al., 2008, Varon et al., 2006). Invadosomes are actin-based structures involved in matrix degradation and cell invasion through metalloproteinases (MMP) activity (Linder et al., 2011). Invadosomes, constitutiv

• Cell Cycle Compound Library Air trapping at the small airway

  2020-02-21

  

  Air-trapping at the small airways is related to severe Cell Cycle Compound Library (Bjermer, 2014), and acute exacerbation (Mahut et al., 2010). Although asthma patients are generally treated with inhaled corticosteroid (ICS) or with ICS and long-acting β2 agonist (LABA), the efficacy of such treat

• The immune control of CMV replication in

  2020-02-21

  

  The immune control of CMV replication in vivo is primarily driven by the T-cell-mediated response, a characteristic that has been proposed as a tool to individualize and therefore to optimize antiviral treatment [6], [7], and it has been associated with spontaneous clearance of CMV viraemia in patie

• br Results Table shows demographics and

  2020-02-21

  

  Results Table 1 shows demographics and clinical features of subjects with obesity and controls. Before surgery five obese were diabetic, only one on glucose-lowering therapy; three obese were dyslipidemic and assumed lipid lowering medications. Lathosterol levels were significantly higher in pati

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