• In attempts to further purify His Artemis numerous

  2020-02-13

  

  In attempts to further purify [His]6-Artemis, numerous matrices were assessed including anion and cation exchange, and ARCA interaction chromatography. The results from these matrices were universally poor (data not shown). Fractionation via adsorption chromatography on a hydroxyapatite (HAP) matri

• ApicomplexansApicomplexans are unicellular and spore

  2020-02-13

  

  ApicomplexansApicomplexans are unicellular and spore-forming obligate intracellular parasites that occupy diverse host niches (Mogi and Kita 2010). They have remodeled mitochondrial carbon and energy metabolism through reductive evolution. The development of novel drugs is now a very serious challen

• The fibrillogenesis process of collagen is understood to ini

  2020-02-13

  

  The fibrillogenesis process of collagen is understood to initiate in the extracellular space near the plasma membrane where secretory vesicles form regions of deep invagination. However, it is not clear how and when collagen-binding proteins interact with collagen molecules during fibrillogenesis or

• Several models show the MAPK pathway

  2020-02-13

  

  Several models show the MAPK pathway involving p38 as the 1478 pathway in pro-inflammatory responses, with the ERK pathway involvement primarily devoted to cell growth and differentiation events (Lai et al., 2001, Widmann et al., 1999). The results of the current study would contradict those models

• Currently phosphodiesterase type PDE inhibitors are

  2020-02-13

  

  Currently, phosphodiesterase type 5 (PDE-5) inhibitors are used widely as the first- line oral treatment for erectile dysfunction of varying causes. Radical prostatectomy for the treatment of prostate cancer is frequently associated with erectile dysfunction, and this type of erectile dysfunction is

• The use of recombinant ER

  2020-02-13

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct Cy5 hydrazide (non-sulfonated) receptor receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the p

• In rodent models the loss of estrogens through ovariectomy

  2020-02-13

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an PAC-1 receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase inhibit

• br Materials and methods br

  2020-02-13

  

  Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic po1 is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacteria such as Lactobacillus plantarum. T

• As small non coding RNAs microRNAs miRNAs can control gene

  2020-02-13

  

  As small non-coding RNAs, microRNAs (miRNAs) can control gene expression at the post-transcriptional level by binding to the 3′-untranslated regions (3′-UTR) of messenger RNAs (mRNA) [15], [16]. miRNAs have been anticipated to regulate virtually all cellular mechanisms [17] and to play an important

• Since the initial identification of DNA ligase inhibitors by

  2020-02-13

  

  Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the

• br Transparency document br Results and

  2020-02-13

  

  Transparency document Results and Discussion Experimental Procedures Acknowledgments The casein kinase 1 (CK1) family consists of at least seven different gene products, often referred to as isoforms (α, β, γ1, γ2, γ3, δ, ε, with splice forms described for CK1α, γ, and ε (reviewed in )

• Nucleophosmin NPM which also plays a role on the

  2020-02-12

  

  Nucleophosmin (NPM1), which also plays a role on the nuclear export of ribosomal proteins and subunits (Maggi et al., 2008), is also a relevant MYC target, presumably through an interaction with CRM1. Conversely, it has been recently reported that specific SINE compounds reduce the levels of MYC in

• Repulsive interactions towards undesirable substrates are

  2020-02-12

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• Previous studies demonstrated that cPLA translocates

  2020-02-12

  

  Previous studies demonstrated that cPLA2α translocates to the phagosomal membrane during macrophage phagocytosis through mechanisms that, in humans, involve phosphorylation of the enzyme by c-Jun N-terminal kinases and membrane association via the cationic cluster of four lysine residues present at

• In vasculature NADPH oxidases NOXs are the

  2020-02-12

  

  In vasculature, NADPH oxidases (NOXs) are the main sources of O2− generation that involve in the transfer of electrons to molecular oxygen. Endothelin-1 [25] and thromboxane A2 [26] were reported to induce eNOS uncoupling via upregulation of NOXs. Additionally, inhibition of p47 phox, a subunit of N

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