• Nucleophosmin NPM which also plays a

  2019-09-23

  

  Nucleophosmin (NPM1), which also plays a role on the nuclear export of ribosomal proteins and subunits (Maggi et al., 2008), is also a relevant MYC target, presumably through an interaction with CRM1. Conversely, it has been recently reported that specific SINE compounds reduce the levels of MYC in

• In brief while previous studies have evaluated

  2019-09-23

  

  In brief, while previous studies have evaluated the individual roles of VDR and ER signaling pathways in breast cancer, in the present study we performed an in silico approach for comparative evaluation of these pathways. Considering the complex interaction networks in the context of cancer, such co

• In rodent models the loss of estrogens through

  2019-09-23

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an N-Benzylacetamidine hydrobromide receptor beta agonist restores its protective effect, but is abolished with the introduction of a nit

• In mammals ribonucleotide reductase RNR is a unique

  2019-09-23

  

  In mammals, ribonucleotide reductase (RNR) is a unique enzyme that catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleoside triphosphates (dNTPs).7, 8 Mammalian RNR consists of two homodimer subunits: the large catalytic dimer RRM1 and the small regulatory dimer RRM2 or RRM2B. An

• Initial investigations in the heart

  2019-09-23

  

  Initial investigations in the heart uncovered Epac as a positive regulator of myocyte hypertrophy [8], [9]. Concomitantly, Epac has been shown to regulate cardiac Ca homeostasis [8], [10], [11], [12], [13]. Ca is an essential second messenger in the cardiac physiology because its rhythmic variations

• br Materials and methods br Results and

  2019-09-23

  

  Materials and methods Results and discussion Conclusions Acknowledgements This work was supported financially by the LIAONING S&T Project (No. 20180550107) and Basic Scientific Research Funds of DLNU (0918110143). Introduction Since 1970s, numerous artificial mimetic enzymes have bee

• Developmental relationships between CD bright and CD dim NK

  2019-09-23

  

  Developmental relationships between CD56bright and CD56dim NK Levonorgestrel mass remain unresolved; however, several studies indicate that the former is a precursor of the latter. An NK subset with intermediate features between CD56bright and CD56dim has been identified, corroborating this develop

• Recent studies have also uncovered additional

  2019-09-23

  

  Recent studies have also uncovered additional roles for E2 enzymes and E2~Ub conjugates in modulating the activity of deubiquitinating enzymes (DUBs), such as OTUB1 (Juang et al., 2012, Wiener et al., 2013, Wiener et al., 2012). Interestingly, OTUB1 has also been shown to associate and modulate the

• Introduction Ubiquitylation is a post translational

  2019-09-23

  

  Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti

• br Conflict of interest br Acknowledgments Dr Hauger

  2019-09-21

  

  Conflict of interest Acknowledgments Dr. Hauger was supported by a BLR&D Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. Dr. Hauger also received support from the VA Center of Excellence for Stress and Mental Healt

• br Materials and methods br Results Recently a quantitative

  2019-09-21

  

  Materials and methods Results Recently, a quantitative proteomic analysis of C2C12 mouse myoblasts cell line totally deprived of protein kinase CK2 catalytic subunits (CK2α/CK2α′(−/−)), suggested that the cellular expression of HSP27, a chaperone with multiple functions related to proteostasis

• br Acknowledgments br Introduction Cholesterol is an essenti

  2019-09-21

  

  Acknowledgments Introduction Cholesterol is an essential lipid for the development, growth, and wellbeing of humans. In newborn children, cord blood cholesterol concentration is 1.5 mmol/l, on average [[1], [2], [3], [4]]. During the first year of life, cholesterol concentration in serum incre

• Our results are the first to demonstrate that

  2019-09-21

  

  Our results are the first to demonstrate that ERRγ acts as a catabolic regulator of cartilage degeneration and OA pathogenesis, and collectively support the idea that ERRγ could be a therapeutic target for OA Introduction DNA cytosine-5-methyltransferases (Dnmts) catalyze the methyl transfer fro

• Upon assembly of HLA tetramers

  2019-09-21

  

  Upon assembly of HLA tetramers loaded with either of the two peptide versions, we could query the T cell repertoires of RA subjects and healthy individuals for the presence of cognate T orexin a recognizing the respective peptide-HLA complexes. We found no significant difference in frequencies of T

• In normal cells the apoptotic stimuli lower

  2019-09-21

  

  In normal cells, the apoptotic stimuli lower the expression level of antiapoptotic proteins by increasing turnover rate and preventing the constant degradation of proapoptotic proteins. Thus, the dysregulation of anti-/pro-apoptotic proteins will confer the survival of cancer CEP-18770 clinical via

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